The markup commands are sticky. This means that when one of the markup styles has been selected (the relevant button in the toolbar is depressed), you can markup any text simply by selecting it: Drag the mouse over the text to be marked, and when you release the drag the selected text is automatically marked up.
To stop marking up selected text click the selected [markup button] to toggle it off.
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Hier ein Video, das schnelle mehrfache Auszeichnungen in der Praxis zeigt.